Alkaline pH block of CLC K kidney chloride channels mediated PubMed
Here we show that ClC K currents are blocked also by alkaline pH with an apparent pK value of ∼ for ClC K1 Using noise analysis we demonstrate that alkaline block is mediated by an allosteric reduction of the open probability By an extensive mutagenic screen we identified K165 a highly conserved residue in the extracellular vestibule